Vehicle 2010 and above need to use Factory Radio parts with our Radio for AC Control
The dashboard picture below is compatible.
(Mid-High Trim)
The dashboard picture below is Low Trim.
2013 Lexus IS 250 can recommend this unit if dash photo looks one below https://phoenixautomotiveinc.com/products/px6-six-core-10-4-vertical-screen-android-9-fast-boot-navigation-radio-for-lexus-is-250-is-300-is-350-2005-2012?_pos=10&_sid=4e7a03b00&_ss=r
This Vehicle Model Not Compatible 
2009 and above move wire pin position - for No Sound
